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The TelegraphRed meat and butter 'could raise Alzheimer's risk'Eating too much red meat, butter and other foods that contain high levels of saturated fats could increase the risk of Alzheimer's, according to a study. By Stephen Adams, Medical Correspondent6:16PM BST 20 May 2012US researchers linked to Harvard University found older women who ate lots of food high in saturated fats had worse memories than others.By contrast, those who ate more monounsaturated fats - found in olive oil, sunflower oil, seeds, nuts and avocados - had better memories.Dr Oliva Okereke, from the Brigham and Women's Hospital in Boston, Mass., which is affiliated to Harvard Medical School, said: "When looking at changes in cognitive function, what we found is that the total amount of fat intake did not really matter, but the type of fat did."She and fellow researchers made their conclusions after looking at results from 6,000 women over 65, who carried out a series of mental tests over four years and answered questionnaires about their diet and lifestyle.Dr Okereke added: "Substituting in the good fat in place of the bad fat is a fairly simple dietary modification that could help prevent decline in memory."Having a poor memory can be a harbinger of Alzheimer's in elderly people, although the former by no means always leads to the latter.The report is published in the journal Annals of Neurology.It follows other research showing a link between high cholesterol and a higher risk of developing Alzheimer's, the most common form of dementia.

John Arthur Forest ● 4894d

Expert Rev Neurother. 2011 May;11(5):677-708.Diet and Alzheimer's disease risk factors or prevention: the current evidence.Solfrizzi V, Panza F, Frisardi V, Seripa D, Logroscino G, Imbimbo BP, Pilotto A.SourceDepartment of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy.AbstractPreventing or postponing the onset of Alzheimer's disease (AD) and delaying or slowing its progression would lead to a consequent improvement of health status and quality of life in older age. Elevated saturated fatty acids could have negative effects on age-related cognitive decline and mild cognitive impairment (MCI). Furthermore, at present, epidemiological evidence suggests a possible association between fish consumption, monounsaturated fatty acids and polyunsaturated fatty acids (PUFA; in particular, n-3 PUFA) and a reduced risk of cognitive decline and dementia. Poorer cognitive function and an increased risk of vascular dementia (VaD) were found to be associated with a lower consumption of milk or dairy products. However, the consumption of whole-fat dairy products may be associated with cognitive decline in the elderly. Light-to-moderate alcohol use may be associated with a reduced risk of incident dementia and AD, while for VaD, cognitive decline and predementia syndromes, the current evidence is only suggestive of a protective effect. The limited epidemiological evidence available on fruit and vegetable consumption and cognition generally supports a protective role of these macronutrients against cognitive decline, dementia and AD. Only recently, higher adherence to a Mediterranean-type diet was associated with decreased cognitive decline, although the Mediterranean diet (MeDi) combines several foods, micro- and macro-nutrients already separately proposed as potential protective factors against dementia and predementia syndromes. In fact, recent prospective studies provided evidence that higher adherence to a Mediterranean-type diet could be associated with slower cognitive decline, reduced risk of progression from MCI to AD, reduced risk of AD and a decreased all-cause mortality in AD patients. These findings suggested that adherence to the MeDi may affect not only the risk of AD, but also of predementia syndromes and their progression to overt dementia. Based on the current evidence concerning these factors, no definitive dietary recommendations are possible. However, following dietary advice for lowering the risk of cardiovascular and metabolic disorders, high levels of consumption of fats from fish, vegetable oils, nonstarchy vegetables, low glycemic index fruits and a diet low in foods with added sugars and with moderate wine intake should be encouraged. Hopefully this will open new opportunities for the prevention and management of dementia and AD.

John Arthur Forest ● 4894d

Arch Neurol. 2010 Jun;67(6):699-706. Epub 2010 Apr 12.Food combination and Alzheimer disease risk: a protective diet.Gu Y, Nieves JW, Stern Y, Luchsinger JA, Scarmeas N.SourceThe Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.AbstractOBJECTIVE:To assess the association between food combination and Alzheimer disease (AD) risk. Because foods are not consumed in isolation, dietary pattern (DP) analysis of food combination, taking into account the interactions among food components, may offer methodological advantages.DESIGN:Prospective cohort study.SETTING:Northern Manhattan, New York, New York.PATIENTS OR OTHER PARTICIPANTS:Two thousand one hundred forty-eight community-based elderly subjects (aged > or = 65 years) without dementia in New York provided dietary information and were prospectively evaluated with the same standardized neurological and neuropsychological measures approximately every 1.5 years. Using reduced rank regression, we calculated DPs based on their ability to explain variation in 7 potentially AD-related nutrients: saturated fatty acids, monounsaturated fatty acids, omega-3 polyunsaturated fatty acids, omega-6 polyunsaturated fatty acids, vitamin E, vitamin B(12), and folate. The associations of reduced rank regression-derived DPs with AD risk were then examined using a Cox proportional hazards model. Main Outcome Measure Incident AD risk.RESULTS:Two hundred fifty-three subjects developed AD during a follow-up of 3.9 years. We identified a DP strongly associated with lower AD risk: compared with subjects in the lowest tertile of adherence to this pattern, the AD hazard ratio (95% confidence interval) for subjects in the highest DP tertile was 0.62 (0.43-0.89) after multivariable adjustment (P for trend = .01). This DP was characterized by higher intakes of salad dressing, nuts, fish, tomatoes, poultry, cruciferous vegetables, fruits, and dark and green leafy vegetables and a lower intake of high-fat dairy products, red meat, organ meat, and butter.CONCLUSION:Simultaneous consideration of previous knowledge regarding potentially AD-related nutrients and multiple food groups can aid in identifying food combinations that are associated with AD risk.

John Arthur Forest ● 4894d

Nutritional Neuroscience 2012 Jan;15(1):1-9.Effects of natural antioxidants in neurodegenerative disease.Albarracin SL, Stab B, Casas Z, Sutachan JJ, Samudio I, Gonzalez J, Gonzalo L, Capani F, Morales L, Barreto GE.SourceDepartamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.AbstractPolyphenols are secondary metabolites with antioxidant properties and are abundant in the diet. Fruits, vegetables, herbs, and various drinks (tea, wine, and juices) are all sources of these molecules. Despite their abundance, investigations into the benefits of polyphenols in human health have only recently begun. Phenolic compounds have received increasing interest because of numerous epidemiological studies. These studies have suggested associations between the consumption of polyphenol-rich aliments and the prevention of chronic diseases, such as cancer, cardiovascular diseases, and neurodegenerative diseases. More specifically, in the last 10 years literature on the neuroprotective effects of a polyphenol-rich diet has grown considerably. It has been demonstrated, in various cell culture and animal models, that these metabolites are able to protect neuronal cells by attenuating oxidative stress and damage. However, it remains unclear as to how these compounds reach the brain, what concentrations are necessary, and what biologically active forms are needed to exert beneficial effects. Therefore, further research is needed to identify the molecular pathways and intracellular targets responsible for polyphenol's neuroprotective effects. The aim of this paper is to present various well-known dietary polyphenols and their mechanisms of neuroprotection with an emphasis on Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.

John Arthur Forest ● 4894d

Current Aging Science. 2012 Sep 27. [Epub ahead of print]Mediterranean Diet and Dementia of the Alzheimer Type.Vassallo N, Scerri C.SourceDepartment of Pathology Faculty of Medicine and Surgery University of Malta, Msida MSD 2080, Malta. charles.scerri@um.edu.mt.AbstractDementia of the Alzheimer type is the most common form of dementia affecting mostly the elderly population. It is a progressive and fatal neurodegenerative disorder with characteristic neuropathology and clinical symptomology. In the coming years, the number of individuals with Alzheimer's disease (AD) will increase as the elderly population worldwide is expected to grow significantly thus putting an added strain on national health care systems as well as caregivers who will inevitably carry most of the care burden. Thus it has been suggested that early intervention strategies which delay or halt the disease progression will have a strong impact on clinical outcomes. Changes in lifestyle habits such as diet modification or supplementationhave been indicated as probable protective factors for a number of chronic conditions including AD. Particular attention has recently been devoted to the Mediterranean diet which is rich in the antioxidants Vitamins C and E, polyunsaturated fatty acids and polyphenolic compounds. Several in vitro, animal and population-based studies reported a positive effect between adherence to a Mediterranean diet and AD prevention, although contrasting views remain. This review will focus on the latest developments and findings in the ongoing research investigating the relationship between Mediterranean diet and its major constituents in AD onset and progression.

John Arthur Forest ● 4894d

American Diabetes AssociationDiabetes Spectrum February 2012 vol. 25 no. 1 38-44 Preparing to Prescribe Plant-Based Diets for Diabetes Prevention and Treatment    Caroline Trapp, MSN, APRN, BC-ADM, CDE and    Susan Levin, MS, RDThe number of people worldwide with type 2 diabetes is expected to double by 2030.1 In the United States, diabetes affects ~ 26 million people of all ages, about one-fourth of whom are not yet diagnosed.2 Despite the availability of a wide range of pharmacological treatments and the best efforts of diabetes educators and other health care professionals, good control of diabetes and its comorbidities remains elusive for much of the population, as evidenced by rates of cardiovascular morbidity and mortality that are two to four times higher than those of people who do not have diabetes.2Although dietary habits and body weight play undisputed roles in type 2 diabetes, the question of what eating pattern best addresses glycemia, cardiovascular risk factors, and weight control remains controversial. The uniform, calorie-controlled diabetic diet plans of the past have been replaced by individualized meal-planning approaches, and in more recent years, nutrition guidance has focused on carbohydrate counting and minimizing saturated and trans fats. With the release of the U.S. Department of Agriculture's 2010 Dietary Guidelines for Americans3 came praise for plant-based eating patterns, which have been extensively studied for weight management and disease prevention and treatment.Individuals following a plant-based eating pattern typically consume fewer calories and less fat, saturated fat, and cholesterol and have lower BMIs than nonvegetarians. They also consume more fiber, potassium, and vitamin C. In prospective studies of adults, compared to nonvegetarian eating patterns, vegetarian eating patterns have been associated with lower prevalence rates of type 2 diabetes,4 cardiovascular disease (CVD),5 hypertension,6 and obesity7,8 and reduced medical care usage.9 Both the American Academy of Nutrition and Dietetics and the American Diabetes Association (ADA) now include well-planned, plant-based eating patterns (vegetarian and vegan) as a meal-planning option in their nutrition recommendations for people with diabetes.10,11 This article provides a brief discussion of research on plant-based eating patterns, relevant nutrition issues, and practical applications for clinicians. Next SectionPrevention of Type 2 DiabetesDiabetes prevalence in the United States is lower among vegetarians than nonvegetarians.12–15 In two large Adventist cohort studies (n = 25,698 and n = 60,903), the prevalence of diagnosed diabetes was 1.6–2.0 times higher among nonvegetarians than among vegetarians or vegans.12,15 Part of the difference is attributable to higher body weight among nonvegetarians, but much of the difference persists after adjustment for body weight.A 2009 study14 found that, among a range of diets from vegan to nonvegetarian, as consumption of animal products increased, so did diabetes prevalence, ranging from 2.9% in vegans to 7.8% among individuals with unlimited consumption of animal products. The article goes on.See:http://spectrum.diabetesjournals.org/content/25/1/38.full

John Arthur Forest ● 4894d

November 4, 2011, doi: 10.1177/1559827611425762 AMERICAN JOURNAL OF LIFESTYLE MEDICINE May/June 2012 vol. 6 no. 3 250-267 Health Implications of a Vegetarian DietA Review    Kate Marsh, BSc, MNutrDiet, PhD    Carol Zeuschner, BSc, MSc    Angela Saunders, BS, MA    Northside Nutrition and Dietetics, Chatswood, Australia    Kate Marsh, BSc, MNutrDiet, PhD, Northside Nutrition and Dietetics, 74/47 Neridah Street, Chatswood NSW 2067, Australia e-mail: kate@nnd.com.au.AbstractThere is now a significant amount of research that demonstrates the health benefits of vegetarian and plant-based diets, which have been associated with a reduced risk of obesity, diabetes, heart disease, and some types of cancer as well as increased longevity. Vegetarian diets are typically lower in fat, particularly saturated fat, and higher in dietary fiber. They are also likely to include more whole grains, legumes, nuts, and soy protein, and together with the absence of red meat, this type of eating plan may provide many benefits for the prevention and treatment of obesity and chronic health problems, including diabetes and cardiovascular disease. Although a well-planned vegetarian or vegan diet can meet all the nutritional needs of an individual, it may be necessary to pay particular attention to some nutrients to ensure an adequate intake, particularly if the person is on a vegan diet. This article will review the evidence for the health benefits of a vegetarian diet and also discuss strategies for meeting the nutritional needs of those following a vegetarian or plant-based eating pattern.

John Arthur Forest ● 4894d

The American Journal of Clinical Nutrition© 2003 American Society for Clinical NutritionType 2 diabetes and the vegetarian diet1,2,3,4David JA Jenkins, Cyril WC Kendall, Augustine Marchie, Alexandra L Jenkins, Livia SA Augustin, David S Ludwig,    Neal D Barnard, and James W AndersonAuthor AffiliationsFrom the Clinical Nutrition & Risk Factor Modification Center (DJAJ, CWCK, AM, ALJ, and LSAA) and the Department of Medicine, Division of Endocrinology and Metabolism (DJAJ), St Michael’s Hospital, Toronto; the Department of Nutritional Sciences, Faculty of Medicine, University of Toronto (DJAJ, CWCK, AM, and LSAA); the Department of Medicine, Children’s Hospital, Boston (DSL); the Physicians Committee for Responsible Medicine, Washington, DC (NDB); and the VA Medical Center, Graduate Center for Nutritional Sciences, University of Kentucky, Lexington (JWA).AbstractBased on what is known of the components of plant-based diets and their effects from cohort studies, there is reason to believe that vegetarian diets would have advantages in the treatment of type 2 diabetes. At present there are few data on vegetarian diets in diabetes that do not in addition have weight loss or exercise components. Nevertheless, the use of whole-grain or traditionally processed cereals and legumes has been associated with improved glycemic control in both diabetic and insulin-resistant individuals. Long-term cohort studies have indicated that whole-grain consumption reduces the risk of both type 2 diabetes and cardiovascular disease. In addition, nuts (eg, almonds), viscous fibers (eg, fibers from oats and barley), soy proteins, and plant sterols, which may be part of the vegetarian diet, reduce serum lipids. In combination, these plant food components may have a very significant impact on cardiovascular disease, one of the major complications of diabetes. Furthermore, substituting soy or other vegetable proteins for animal protein may also decrease renal hyperfiltration, proteinuria, and renal acid load and in the long term reduce the risk of developing renal disease in type 2 diabetes. The vegetarian diet, therefore, contains a portfolio of natural products and food forms of benefit for both the carbohydrate and lipid abnormalities in diabetes. It is anticipated that their combined use in vegetarian diets will produce very significant metabolic advantages for the prevention and treatment of diabetes and its complications.To read further please go to:http://ajcn.nutrition.org/content/78/3/610S.abstract?sid=5b10b0ac-f7ca-4947-bdfb-53836428c691

John Arthur Forest ● 4894d